Pointe Fentanyl Open Channel Reagent: A FDA approved, qualitative solution for testing Fentanyl and Norfentanyl
Fentanyl is
50 to 100 Times
More Potent
than morphine *
What are the Effects of Fentanyl:
- Sedation
- Confusion
- Extreme Happiness
- Problems Breathing
- Nausea
- Constipation
- Unconsciouness *
Pointe Brand Fentanyl is the Superior Choice
Pointe Fentanyl Open Channel Reagent is FDA cleared and designed for prescription use on a number of automated clinical chemistry analyzers. The Pointe Fentanyl reagent is intended for the qualitative determination of norfentanyl in human urine at the cutoff value of 5 ng/mL. This is important because up to 85% of fentanyl is excreted over 3-4 days and only 26-55% of norfentanyl is excreted in that same time frame.
A Drug by Many Names...
Fentanyl is known as:
| Prescription Names: | Street Names: |
| Actiq® | Apache |
| Duragesic® | China White |
| Sublimaze® | Jackpot * |
A Drug Sold in Many Forms...
Illegal Fentanyl is sold as:
| Powder | Nasal Sprays |
| Dropped onto blotter paper | Pills |
| Eye droppers * | |
Why Norfentanyl Testing Matters
- Fentanyl is rapidly metabolized to its major inactive metabolite,
norfentanyl **
- Drugs that are rapidly metabolized (have a short half-life), such as fentanyl, are mainly detected indirectly by their metabolites. ***
• Fentanyl’s half life is anywhere from 3-12 hours *****
• Norfentanyl’s half life is 9-10 hours *****
- Only immunoassays specifically directed toward the molecule will detect synthetic opioids, such as methadone or fentanyl ***
- The most common reasons for opioid false-negative results are using incorrect testing for a specific opioid or there is insufficient concentration of opioid in the urine **
On the Rise ****
References:
* https://www.drugabuse.gov/publications/drugfacts/fentanyl#ref
** Clinical Interpretation of Urine Drug Tests, Moeller, Karen E. et al., Mayo Clinic Proceedings, Volume 92, Issue 5, 774 – 796
*** https://www.remitigate.com/wp-content/uploads/2015/11/urine-Drug-Testing-in-Clinical-Practice-Ed6_2015-08.pdf
**** Data collected from Virginia Commonwealth University Health System (VCU Health) has collected a data set specifically from pain management compliance patients over the last three years (November 1, 2015 – October 31, 2018).
***** https://www.aruplab.com/files/resources/pain-management/DrugAnalytesPlasmaUrine.pdf
