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Creatinine Enzymatic


(Assays)

Catalog #: CEE480

METHOD

Enzymatic

TECHNICAL INFORMATION

Format: Liquid
Wavelength: 546 nm
Linearity: 0.01-30.0 mg/dL
Expected Values: Male (serum): 0.9 - 1.5 mg/dL, Female (serum): 0.7 - 1.4 mg/dL, Male (urine): 1000 - 2000 mg/24hrs, Female (urine): 600 - 1500 mg/24hrs
Storage Temperature: 2-8°C
Reconstituted Stability: Ready to use liquid
  • Description
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Intended Use

For the quantitative enzymatic determination of creatinine in serum and urine on the Mindray BS-480. For In Vitro Diagnostic Use Only.

Principle

Creatinine is a catabolic product of creatine, which is used in skeletal muscle contraction. The daily production of creatine, and subsequently creatinine, depends on muscle mass, which fluctuates very little. Creatinine is excreted entirely by the kidneys and therefore is directly proportional to renal excretory function. Thus with normal renal excretory function, the serum creatinine level should remain constant and normal. Only renal disorders, such as glomerulonephritis, pyelonephritis, acute tubular necrosis, and urinary obstruction, will cause an abnormal elevation in creatinine.1

The current method employs a two reagent system which eliminates interference by endogenous creatine and ascorbic acid.

1. Pagana, KD and TJ Pagana, Mosby's Diagnostic and Laboratory Test Reference, 2nd Ed., Mosby, St. Louis, 1995, p.270.